Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica
نویسندگان
چکیده
منابع مشابه
Tumefactive Brain Lesions in Patients with Neuromyelitis Optica Spectrum Disorder
Background: Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune neurological disorder that is characterized by optic neuritis and longitudinally-extended transverse myelitis lesions in spinal segments. Magnetic Resonance Imaging (MRI) findings are part of the diagnostic process in NMOSD patients, and abnormal lesion patterns may cause deviation from a correct diagnosis. Clinical P...
متن کاملDisruption of the leptomeningeal blood barrier in neuromyelitis optica spectrum disorder
OBJECTIVE To describe leptomeningeal blood-barrier impairment reflected by MRI gadolinium-enhanced lesions in patients with aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD). METHODS A retrospective case series of 11 AQP4-IgG-positive NMOSD patients with leptomeningeal enhancement (LME) were collected from 5 centers. External neuroradiologists, bl...
متن کاملMarkedly Increased IP-10 Production by Blood-Brain Barrier in Neuromyelitis Optica
OBJECTIVE Severe damage to the blood-brain barrier (BBB) allows anti-aquaporin 4 (AQP4) antibodies to access the astrocytic endfeet in neuromyelitis optica (NMO). In the current study, we identified the pathogenic cytokines/chemokines that are responsible for the BBB malfunction induced by NMO sera. METHODS We measured the levels of 27 cytokines/chemokines in human brain microvascular endothe...
متن کاملGRP78 autoantibodies initiate the breakdown of the blood-brain barrier in neuromyelitis optica
Antibody-based therapy offers vast potential in the treatment of several neurodegenerative diseases. Many drug companies are now engineering antibodies targeting β-amyloid protein for Alzheimer disease and α-synuclein protein for Parkinson disease. However, the development of antibody-based therapies against the central nervous system (CNS) diseases has lagged, partly due to the poor blood-brai...
متن کاملEffects of neuromyelitis optica–IgG at the blood–brain barrier in vitro
OBJECTIVE To address the hypothesis that physiologic interactions between astrocytes and endothelial cells (EC) at the blood-brain barrier (BBB) are afflicted by pathogenic inflammatory signaling when astrocytes are exposed to aquaporin-4 (AQP4) antibodies present in the immunoglobulin G (IgG) fraction of serum from patients with neuromyelitis optica (NMO), referred to as NMO-IgG. METHODS We ...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2017
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.aai9111